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Physical Activity and Diabetes

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes 


Cynthia M. F. Monaco & Meghan C. Hughes & Sofhia V. Ramos & Nina E. Varah & Christian Lamberz & Fasih A. Rahman & Chris McGlory & Mark A. Tarnopolsky & Matthew P. Krause & Robert Laham & Thomas J. Hawke & Christopher G. R. Perry

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Abstract

Skeletal muscle, by virtue of its mass and its high capacity to burn sugar as a fuel, is perhaps the main determinate of blood sugar control in diabetes. Impairments to the mitochondria (the powerhouse of the cell) found within skeletal muscle have been implicated in the progression of a number of diseases including type 2 diabetes and cancer cachexia. However, whether the mitochondria in skeletal muscle are adversely affected in physically-active young adults with type 1 diabetes has yet to be determined.  If present (and left unchecked), these changes could affect the ability to manage blood glucose levels and may be responsible for the more rapid onset of disability with advancing age.

In a recent publication in Diabetologia (link below), a leading diabetes research journal, we show that type 1 diabetes can be associated with a reduction in the ability of mitochondria to generate energy, while at the same time, increasing the amount of oxidative stress within the muscle.  The changes lead to visible increases in ‘debris’ within the skeletal muscle of those with type 1 diabetes.  Despite these negative alterations, we did not see evidence of a loss of mitochondrial or blood vessel content in the muscle, suggesting that it is the quality of the mitochondria that is likely impacted by the disease condition. Given that our subjects were self-reporting physical activity levels that exceed the recent Diabetes Canada Clinical Practise Guideline on physical activity (link below), it is likely that their level of activity was preventing the full extent of impairments that would exist were they leading an inactive (sedentary) lifestyle.

Taken together, our findings indicate that the current exercise guidelines for those with type 1 diabetes may be insufficient to fully prevent skeletal muscle metabolic abnormalities in young adults and further research is needed to identify therapeutic strategies (e.g. optimal exercise prescription) that can maximize muscle health in those with type 1 diabetes.

Diabetologia manuscript:

https://link.springer.com/article/10.1007/s00125-018-4602-6
Dskate would like to thank Michael Riddell, Tom Hawke, Chris Perry and all collaborating colleagues for providing us with the links and information as well as for their hard work and dedication to the subject matter. We are grateful for their passion to make a difference. 
 

For more information, please feel free to contact Tom Hawke hawke@mcmaster.ca or Chris Perry cperry@yorku.ca


Physical Activity and Diabetes 

Diabetes Canada Clinical Practice Guidelines Expert Committee


Ronald J. Sigal MD, MPH, FRCPC, Marni J. Armstrong CEP, PhD, Simon L. Bacon PhD, Normand G. Boulé PhD, Kaberi Dasgupta MD, MSc, FRCPC, Glen P. Kenny PhD, Michael C. Riddell PhD

https://www.canadianjournalofdiabetes.com/article/S1499-2671(17)30818-3/pdf


 

KEY MESSAGES FOR PEOPLE WITH DIABETES 

 

• Physical activity often improves glucose control and facilitates weight loss, but has multiple other health benefits even if weight and glucose control do not change. 

• It is best to avoid prolonged sitting. Try to interrupt sitting time by getting up briefly every 20 to 30 minutes.

• Try to get at least 150 minutes per week of aerobic exercise (like walking, bicycling or jogging).

• Using a step monitor (pedometer or accelerometer) can be helpful in tracking your activity.

• In addition to aerobic exercise, try to do at least 2 sessions per week of strength training (like exercises with weights or weight machines).

• If you decide to begin strength training, you should ideally get some instruction from a qualified exercise specialist.

• If you cannot reach these recommended levels of activity, doing smaller amounts of activity still has some health benefits.

 

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